Life hack: sickle cell patients get all the narcotics they want in the hospital

For the curious: https://www.nejm.org/doi/10.1056/NEJMoa072464?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0www.ncbi.nlm.nih.gov

For those who don’t know there are two main pathways in which the cell produces energy and precursors. Glycolysis and TCA cycle. And the pyruvate kinase (PK) is one of the last steps of glycolysis. Glycolysis functioning is imperative for rapid energy production from glucose, and that’s why we love sugar (e.g. glucose). I.e. I don’t think this deficiency is overall a great solution 🫣